Eli D. Sone | BSc (Toronto), MS, PhD (Northwestern)
Joint-appointed with the Institute of Biomedical Engineering (BME)
Office: MB 320A
Research Group: Biological and Bioinspired Materials Laboratory
My research program is centered on the study of composite biological and bioinspired materials, with emphasis and bio-mineralization and bioadhesion phenomena. Areas of application include development of novel bio-adhesives and tissue engineering scaffolds.
Our work is focused on systems in biology where organic-mineral interactions play a key role. We use a combination of ultra-structural characterization of native tissues and in-vitriol investigations of synthetic systems to study the mechanisms of attachment of biological fibers to inorganic substrates. Currently we are working on two systems in which the structure of the interface is critical: adhesion of zebra mussels to rocks, and the attachment of ligaments to bones and teeth. We use a variety of techniques to study these systems; cryo-TEM in particular plays a central role in our work.
Lausch, AJ; Chong, LC; Uludag, H; Sone, ED. “Multiphasic collagen scaffolds for engineered tissue interfaces” Advanced Functional Materials 2018, 28, 1804730
Quan, BD; Sone, ED. “The effect of polyaspartate chain length on mediating biomimetic remineralization of collagenous tissues”, Journal of the Royal Society Interface 15: 20180269. http://dx.doi.org/10.1098/rsif.2018.0269, 2018
Rees DJ, Hanifi A, Manion J, Gantayet A and Sone ED. Spatial distribution of proteins in the quagga mussel adhesive apparatus. Biofouling. 2016, 32, 205-13
Sone, E. D.; Weiner, S.; Addadi, L. “Morphology of goethite crystals in developing limpet teeth: Assessing biological control over mineral formation” Crystal Growth and Design 2005 5, 2131-2138.
Sone, E. D.; Zubarev, E. R.; Stupp, S. I. “Supramolecular templating of single and double nanohelices of cadmium sulfide” Small 2005 1, 694-697.
Sone, E. D.; Stupp, S. I. “Semiconductor-encapsulated peptide-amphiphile nanofibers” Journal of the American Chemical Society 2004 126, 12756-12757.
Sone, E. D.; Zubarev, E. R.; Stupp, S. I. “Semiconductor nanohelices templated by supramolecular ribbons” Angewandte Chemie International Edition in English 2002 41, 1705-1709.