Naomi Matsuura | BScEng, MScEng (Queen’s), PhD (Toronto), PEng
Joint-appointed with the Institute of Biomedical Engineering (IBME)
Office: RS 405
Research Group: Nanotechnology, Molecular Imaging & Systems Biology
New directions in cancer imaging: Activating drugs in situ
Professor Matsuura’s Medical Imaging Materials Laboratory specializes in designing new materials that interact strongly and specifically with imaging radiation.
A major application of such materials is their use towards guiding personalized treatment of cancer for individual patients. These new materials, in the form of injectable colloids, may be remotely activated using medical imaging sources to facilitate the minimally-invasive, image-guided, local and site-specific delivery of cancer therapies to tumours in vivo, even to organs that are typically difficult to treat using systemic drug therapies (e.g., the brain).
Recently, her group has also developed a new biocompatible and clinically translatable nanoscale agent for radiosensitization of hypoxic tumours.
Her research program spans across multiple disciplines; from synthetic chemistry to physicochemical characterization, preclinical evaluation in vivo, and commercialization, with the eventual goal of clinical translation in partnership with clinical collaborators.
Perfluorocarbon nanodroplets can reoxygenate hypoxic tumors in vivo without carbogen breathing
Multiwavelength Surface-Enhanced Raman Spectroscopy Using Rainbow Trapping in Width-Graded Plasmonic Gratings
2018; Advanced Optical Materials;
Multispectral SERS using plasmonic width-graded nanogratings
2018; Proceedings of SPIE – The International Society for Optical Engineering;
18F-Labeled perfluorocarbon droplets for positron emission tomography imaging
2017; Nuclear Medicine and Biology;
Methods of generating submicrometer phase-shift perfluorocarbon droplets for applications in medical ultrasonography
2017; IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control;
M. Seo, R. Williams, and N. Matsuura, “Size reduction of cosolvent-infused microbubbles to form acoustically responsive monodisperse perfluorocarbon nanodroplets.” Lab on a Chip 15, 3581-3590 (2015)
M. Seo and N. Matsuura, “Direct incorporation of lipophilic nanoparticles into monodisperse, perfluorocarbon nanodroplets via solvent-dissolution from microfluidic-generated precursor microdroplets.” Langmuir 30 (42) 12465-12473 (2014)
M. L. Hill, I. Gorelikov, F. Niroui, R. B. Levitin, J. G. Mainprize, M. J. Yaffe, J. A. Rowlands, and N. Matsuura, “Feature Article: Towards a nanoscale mammographic contrast agent: development of a modular pre-clinical dual optical/x-ray agent.” Physics in Medicine and Biology 58 (15), 5215-5235 (2013)
A. L. Martin, M. Seo, R. Williams, G. Belayneh, F. S. Foster and N. Matsuura, “Intracellular growth of nanoscale perfluorocarbon droplets for enhanced ultrasound-induced phase-change conversion.” Ultrasound Medicine and Biology, 38 (10), 2704-2714 (2012)
M. Seo and N. Matsuura, “Monodisperse, sub-micrometer droplets via condensation of microfluidic-generated gas bubbles.” Small, 8 (17), 2704-2714 (2012)
I. Gorelikov, A. L. Martin, M. Seo, and N. Matsuura, “Silica-coated quantum dots for optical evaluation of perfluorocarbon droplet interaction with cells,” Langmuir, 27 (24), 15024-15033 (2011)
M. Seo, I. Gorelikov, R. Williams, and N. Matsuura, “Microfluidic assembly of monodisperse, nanoparticle-incorporated perfluorocarbon microbubbles for medical imaging and therapy.”Langmuir, 26 (17), 13855–13860 (2010)
N. Matsuura and J. A. Rowlands, “Towards new functional nanostructures for medical imaging.”Medical Physics, 35, 4474-4487 (2008)
I. Gorelikov and N. Matsuura, “Single-step coating of mesoporous silica on cetyltrimethyl ammonium bromide-capped nanoparticles.” Nano Letters, 8, 369-373 (2008)