3M: Mining the Microscopy Makerspace
Recent developments in microscopy have enabled powerful insights into local molecular, cellular, and tissue-level structure and dynamics. Our lab has been focusing on the development and application of several combinatorial microscopy platforms, including hyperspectral super-resolution, light sheet/selective plane illumination, and full-field optical coherence tomography. The application of these tools to quantitative analysis of biomolecular self-assembly, membrane receptor self-association, protein-protein interactions, and developmental processes will be described. The key technical challenges that underpin these approaches, and the opportunities that they provide will be discussed.
About the speaker
Professor Christopher Yip, BASc (Toronto), PhD (Minnesota), FAAAS, FEIC, PEng
Professor & Director, Institute of Biomaterials and Biomedical Engineering
Department of Chemical Engineering & Applied Chemistry
Prof. Christopher Yip is a leading voice in the research area of single-molecule biophysics. He is a faculty member with both the Department of Chemical Engineering & Applied Chemistry and the Department of Biochemistry, the Institute of Biomaterials and Biomedical Engineering, and is a Principal Investigator with the Donnelly Centre for Cellular & Biomolecular Research at the University of Toronto. Prof. Yip’s research interests are in molecular engineering and single molecule biophysics, specifically the in situ characterization of molecular self-assembly, which has clear implications for understanding processes ranging from the crystallization of biomolecules and pharmaceuticals to the interaction of protein and drug molecules with cellular membranes.
As Director of the Institute of Biomaterials & Biomedical Engineering (IBBME), Professor Christopher Yip provides leadership to more than 80 research engineers and scientists throughout the greater Toronto area that are engaged in discovery and product development in the areas of neuroscience and sensory stimulation, biomaterials and tissue engineering, molecular systems biology and nanotechnology, as well as medical device and drug delivery system design.