Correlative Microscopies for Investigating Bone and Biomaterials Interfaces
Uncovering the mechanisms of biomaterial-tissue interactions is complicated by the complex and 3D hierarchical structure of bone. Elucidating the multi length-scale spatial and chemical structure of bone has the potential to shed light on bonding mechanisms and lead to improvements in the design of biomaterials for joint replacement and dental applications. In our work we explore the structure, formation and attachment of bone to biomaterials with advanced microscopy approaches. This talk will introduce a range of correlative 3D approaches to investigate mineralized bone and the bone-implant interface, including X-ray computed tomography, electron tomography, electron energy loss spectroscopy tomography, and atom probe tomography. We reveal structural and chemical heterogeneities in bone and at biointerfaces. These correlative microscopies provide a foundation for understanding the structure and chemical nature of inorganic and organic hierarchical materials.
About the Speaker
Professor Kathryn Grandfield
Department of Materials Science and Engineering, School of Biomedical Engineering, McMaster University, Canada
Dr. Kathryn Grandfield leads the Grandfield Research Group, and is a Dean’s Honour Role instructor for both undergraduate and graduate curriculum. She is presently second Vice-President of the Microscopical Society of Canada, elected board member for the Canadian Biomaterials Society, and Director of User Operations at the Canadian Centre for Electron Microscopy. Dr. Grandfield is the 2017 recipient of the Petro Canada – McMaster University Young Innovator Award.
The Grandfield Research Group focuses on the development and multi-length scale characterization of biomaterials for bone interfacing applications in orthopedics and dentistry. This research is pioneering the investigation of bone-implant interfaces and mineralized tissues with multi-dimensional (3D and 4D) and high-resolution microscopies, such as electron and atom probe tomography. The insights made through this work are contributing to the design of novel materials for improved implant success, and improved understanding of healthy and pathological bone. Other research themes in our group include the development and surface modification of bone scaffolds and implants, including 3D-printing and laser-modification.
Her research interests include: biomaterials; osseointegration; electron microscopy; mineralized tissues; electron tomography; atom probe tomography